I have been an RSS-readin' machine since I saw this post on Robert Scoble and his 622 feed subscriptions. I now follow his lead and start with "All items" in Google Reader. I make a first pass using the shortcuts (s for star, j for next item, k for previous item), starring anything that sounds vaguely interesting. Then I hit gs to go to the starred items. Then I have a leisurely read, unstarring as I go. If there's something I want to read, but don't have time, I just leave it starred for the next time. Those shortcuts sure are better than mousing!